Diversion Control Division, US Department of Justice, Drug Enforcement Administration

Chemical Handler's Manual

APPENDIX F – Table of Concentration Limits for Exempt Chemical Mixtures

Information regarding this subject may be found at 21 C.F.R. § 1310.12.

The below listed chemical mixtures, in the concentrations specified, are exempted from application of the requirement of registration and from recordkeeping and reporting requirements. No exemption granted affects the criminal liability for illegal possession, distribution, exportation, or importation of listed chemicals contained in the exempt chemical mixture or the civil liability for unlawful acts relating to exempt chemical mixtures, including distribution, in violation of 21 U.S.C. § 842(a)(11).

Mixtures containing a listed chemical in concentrations equal to or less than those specified in the table below are designated as exempt chemical mixtures. The concentration is determined for liquid-liquid mixtures by using the volume or weight and for mixtures containing solids or gases by using the unit of weight.

The DEA may, at any time, terminate or modify the exemption for any chemical mixture in this appendix. Details regarding such termination or modification may be found at 21 C.F.R. § 1310.12(e).

The DEA may also modify any part of the criteria for exemption upon evidence of diversion or attempted diversion. Details regarding such modification may be found at 21 C.F.R. § 1310.12(f).

List I Chemicals DEA Chemical Code Number Concentration Special conditions
N-Acetylanthranilic acid, its salts and esters 8522 20% by weight Concentration based on any combination of N-acetylanthranilic acid and its salts and esters.
Anthranilic acid, and its salts and esters. 8530 50% by weight Concentration is based on any combination of anthranilic acid and its salts and esters.
Benzaldehyde 8256 50% by weight or volume  
Benzyl cyanide 8570 20% by weight or volume  
Ephedrine, its salts, optical isomers, and salts of optical isomers. 8113 Not exempt at any concentration Chemical mixtures containing any amount of ephedrine and/or pseudoephedrine, and their salts, optical isomers and salts of optical isomers are not exempt due to concentration, unless otherwise exempted.
Ergocristine and its salts 8612 Not exempt at any concentration. Chemical mixtures containing any amount of ergocristine and its salts are not exempt.
Ergonovine and its salts 8675 Not exempt at any concentration Chemical mixtures containing any amount of ergonovine, including its salts, are not exempt
Ergotamine and its salts 8676 Not exempt at any concentration Chemical mixtures containing amount of any ergotamine, including its salts, are not exempt.
Ethylamine and its salts 8678 20% by weight or volume Ethylamine or its salts in an inert carrier solvent is not considered a mixture. Concentration is based on ethylamine in the mixture and not the combination of ethylamine and carrier solvent, if any.
Gamma-Butyrolactone 2011 70% by weight or volume  
Hydriodic acid 6695 20% by weight or volume  
Hypophosphorous Acid and its salts 6797 30% by weight if a solid, weight or volume if a liquid The weight is determined by measuring the mass of hypophosphorous acid and its salts in the mixture, the concentration limit is calculated by summing the concentrations of all forms of hypophosphorous acid and its salts in the mixture. The DEA does not consider a chemical mixture to mean the combination of a listed chemical and an inert carrier. Therefore, any solution consisting of hypophosphorous acid (and its salts), dispersed in water, alcohol, or another inert carrier, is not considered a chemical mixture and is therefore subject to chemical regulatory controls at all concentrations.
Iodine 6699 2.2 Calculated as weight/volume (w/v)
Isosafrole 8704 20% by weight or volume Concentration in a mixture cannot exceed 20% if taken alone or in any combination with safrole.
Methylamine and its salts 8520 20% by weight Methylamine or its salts in an inert carrier solvent is not considered a mixture. Weight is based on methylamine in the mixture and not the combined weight of carrier solvent, if any.
3,4-Methylenedioxyphenyl-2-propanone 8502 20% by weight  
N-Methylephedrine, its salts, optical isomers, and salts of optical isomers. 8115 0.1% by weight Concentration based on any combination of salts N- methylephedrine, N- methylpseudoephedrine and their salts, optical isomers and salts of optical isomers.
N-Methylpseudoephedrine, its salts, optical isomers, and salts of optical isomers. 8119 0.1% by weight Concentration based on any combination of N- methylpseudoephedrine, N- methylephedrine, and their salts, optical isomers and salts of optical isomers.
Nitroethane 6724 20% by weight or volume  
Norpseudoephedrine, its salts, optical isomers, and salts of optical isomers. 8317 0.6% by weight Concentration based on any combination of norpseudoephedrine, phenylpropanolamine and their salts, optical isomers and salts of optical isomers.
N-phenethyl-4-piperidone (NPP) 8332 Not exempt at any concentration Chemical mixtures containing any amount of NPP are not exempt.
Phenylacetic acid, and its salts and esters. 8791 40% by weight Concentration is based on any combination of phenylacetic acid and its salts and esters.
Phenylpropanolamine, its salts, optical isomers, and salts of optical isomers. 1225 0.6% by weight Concentration based on any combination of phenylpropanolamine, norpseudoephedrine and their salts, optical isomers and salts of optical isomers.
Phosphorus (red) 6795 80% by weight  
Phosphorus (white or yellow) 6796 Not exempt at any concentration. Chemical mixtures containing any amount of white phosphorus are not exempt due to concentration, unless otherwise exempted.
Piperidine, and its salts 2704 20% by weight or volume Concentration based on any combination of piperidine and its salts. Concentration based on weight if a solid, weight or volume if a liquid.
Piperonal 8750 20% by weight or volume  
Propionic anhydride 8328 20% by weight or volume  
Pseudoephedrine, its salts, optical isomers, and salts of optical isomers. 8112 Not exempt at any concentration Chemical mixtures containing any amount of ephedrine and/ or pseudoephedrine, and their salts, optical isomers and salts of optical isomers are not exempt due to concentration, unless otherwise exempted.
Safrole 8323 20% by volume Concentration in a mixture cannot exceed 20% if taken alone or in any combination with isosafrole.
List II Chemicals DEA Chemical Code Number Concentration Special conditions
Acetic Anhydride 8519 20% by weight or volume  
Acetone 6532 35% by weight or volume Exports only; Limit applies to acetone or any combination of acetone, ethyl ether, 2-butanone, methyl isobutyl ketone, and toluene if present in the mixture by summing the concentrations for each chemical.
Benzyl chloride 8568 20% by weight or volume  
2-butanone 6714 35% by weight or volume Exports only; Limit applies to 2-butanone or any combination of acetone, ethyl ether, 2-butanone, methyl isobutyl ketone, and toluene if present in the mixture by summing the concentrations for each chemical.
Ethyl ether 6584 35% by weight or volume Exports only; Limit applies to ethyl ether or any combination of acetone, ethyl ether, 2-butanone, methyl isobutyl ketone, and toluene if present in the mixture by summing the concentrations for each chemical.
Hydrochloric acid 6545 20% by weight or volume Hydrogen chloride in an inert carrier solvent, such as aqueous or alcoholic solutions, is not considered a mixture. Weight is based on hydrogen chloride in the mixture and not the combined weight of the carrier solvent, if any.
Methyl isobutyl ketone 6715 35% by weight or volume Exports only pursuant to 21 C.F.R. § 1310.08; limit applies to methyl isobutyl ketone or any combination of acetone, ethyl ether, 2-butanone, methyl isobutyl ketone, and toluene if present in the mixture by summing the concentrations for each chemical.
Potassium permanganate 6579 15% by weight  
Sodium permanganate 6588 15% by weight  
Sulfuric acid 6552 20% by weight or volume Sulfuric acid in an inert carrier solvent, such as aqueous or alcoholic solutions, is not considered a mixture. Weight is based on sulfuric acid in the mixture and not the combined weight of the carrier solvent, if any.
Toluene 6594 35% by weight or volume Exports only; Limit applies to toluene or any combination of acetone, ethyl ether, 2-butanone, methyl isobutyl ketone, and toluene if present in the mixture by summing the concentrations for each chemical.

Appendix ETable of Contents | Appendix G

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