Diversion Control Division, US Department of Justice, Drug Enforcement Administration

REGISTRATION > Applications > DEA Form 224 - New Application for Registration

DEA Form 224 - New Application for Registration



Information must be typed or printed in the blocks provided to help reduce data entry errors. A physical address is required in address line 1; a post office box or continuation of address may be entered in address line 2. Fee exempt applicant must list the address of the federal or state fee exempt institution.

Applicant must enter a valid social security number (SSN), or a tax identification number (TIN) if applying as a business entity. Debt collection information is mandatory pursuant to the Debt Collection Improvement Act of 1996

The email address, point of contact, national provider id, date of birth, year graduated, and professional school are new data items that are used to facilitate communication or as required by inter-agency data sharing requirements. They are requested in order to facilitate communication or as required by inter-agency data sharing requirements.

Practitioner must enter one degree from this list: DDS, DMD, DO, DPM, DVM, or MD.
Mid-level practitioner must enter one degree from this list: DOM, HMD, MP, ND, NP, OD, PA, or RPH.


Indicate only one. Practitioner or mid-level practitioner must enter the degree conferred, and are requested to enter the last professional school of matriculation and the year graduated.

Automated dispensing system (ADS) must provide current DEA registration number of parent retail pharmacy or hospital, and attach a notarized affidavit in accordance with 21 CFR Part 1301.17. Affidavit must include:

  1. Name of parent retail pharmacy or hospital and complete address
  2. Name of Long-term Care (LTC) facility and complete address
  3. Permit or license number(s) and date issued of State certification to operate ADS at named LTC facility
  4. Required Statement:
    This affidavit is submitted to obtain a DEA registration number. If any material information is false, the Administrator may commence proceedings to deny the application under section 304 of the Act (21 U.S.C. 8224(a)). Any false or fraudulent material information contained in this affidavit may subject the person signing this affidavit, and the named corporation/partnership/business to prosecution under section 403 of the Act (21 U.S.C 843).
  5. Name of corporation operating the retail pharmacy or hospital
  6. Name and title of corporate officer signing affidavit
  7. Signature of authorized officer


Applicant should check all drug schedules to be handled. However, applicant must still comply with state requirements; federal registration does not overrule state restrictions. Check the order form box only if you intend to purchase or to transfer schedule 2 controlled substances. Order forms will be mailed to the registered address following issuance of a Certificate of Registration. The following list of drug codes are examples of controlled substances for narcotic and non-narcotic schedules 2, 3, 4, and 5. Refer to the CFR for a complete list of basic classes.

Schedule II

Alphaprodine (Nisentil) 9010
Anileridine (Leritine) 9020
Cocaine (Methyl Benzoylecgonine) 9041
Codeine (Morphine methyl ester) 9050
Dextropropoxyphene (bulk) 9273
Diphenoxylate 9170
Diprenorphine (M50-50) 9058
Ethylmorphine (Dionin) 9190
Etorphine Hydrochloride (M-99) 9059
Glutethimide (Doriden, Dorimide) 2550
Hydrocodone (Dihydrocodeinone) 9193
Hydromorphone (Dialudid) 9150
Levo-alphacetylmethadol (LAAM) 9648
Levorphanol (Levo-Dromoran) 9220
Meperidine (Demerol, Mepergan) 9230
Methadone (Dolophine, Methadose) 9250
Morphine (MS Contin, Roxanol) 9300
Opium, powdered 9639
Opium, raw 9600
Oxycodone (Oxycontin, Percocet) 9143
Oxymorphone (Numorphan) 9652
Opium Poppy / Poppy Straw 9650
Poppy Straw Concentrate 9670
Thebaine 9333
Amobarbital (Amytal, Tuinal) 2125
Amphetamine (Dexedrine, Adderall) 1100
Methamphetamine (Desoxyn) 1105
Methylphenidate (Concerta, Ritalin) 1724
Pentobarbital (Nemutal) 2270
Phencyclidine (PCP) 7471
Phenmetrazine (Preludin) 1631
Phenylacetone 8501
Secobarbital (Seconal) 2315

Schedule III

Buprenorphine (Buprenex, Temgesic, Subutex 9064
Codeine combo product up to 90 mg/du (Empirin) 9804
Dihydrocodeine combo prod 90 mg/du (Compal) 9807
Ethylmorphine combo product 15 mg/du 9808
Hydrocodone combo product (Lorcet, Vicodin) 9806
Morphine combo product 50 mg/100ml or gm 9810
Opium combo product 25 mg/du (Paregoric) 9809
Anabolic Steroids 4000
Benzphetamine (Didrex, Inapetyl) 1228
Butalbital (Fiorinal, Butalbital w/aspirin) 2100/2165
Dronabinol in sesame oil w/soft gelatin capsule 7369
Gamma Hydroxybutyric Acid preps (Zyrem) 2012
Ketamine (Ketaset) 7285
Methyprylon (Noludar) 2575
Pentobarbital suppository du & noncontrolled active ingred. (FP-3, WANS) 2271
Phendimetrazine (Plegine, Bontril, Statobex 1615
Secobarbital suppository du & noncontrolled active ingredients 2316
Thiopental (Pentothal) 2100/2329
Vinbarbital (Delvinal 2100/2329

Schedule IV

Alprzolam (Xanax) 2882
Barbital (Veronal, Plexonal, Barbitone) 2145
Chloral Hydrate (Noctec) 2465
Chlordiazepoxide (Librium, Libritabs) 2744
Clorazepate (Tranxene) 2768
Dextropropoxyphene du (Darvon) 9278
Diazepam (Valium, Diastat) 2765
Diethylpropion (Tenuate, Tepanil) 1610
Difenoxin 1mg/25ug atropine SO4/du (Motofen) 9167
Fenfluramine (Pondimin, Dexfenfluramine) 1670
Flurazepam (Dalmane) 2767
Halazepam (Paxipam) 2762
Lorazepam (Ativan) 2885
Mazindol (Sanorex, Mazanor) 1605
Mebutamate (Capla) 2800
Meprobamate (Miltown, Equanil) 2820
Methohexital (Brevital 2264
Methylphenobarbital (Mebaral) 2250
Midazolam (Versed) 2884
Oxazepam (Serax, Serenid-D)) 2835
Paraldehyde (Paral) 2585
Pemoline (Cylert) 1530
Pentazocine (Talwin, Talacen) 9709
Phenobarbital (Luminal, Donnatal) 2285
Phentermine (Ionamin, Fastin, Zantryl) 1640
Prazepam (Centrax) 2764
Quazepam (Doral) 2881
Temazepam (Restoril) 2925
Triazolam (Halcion) 2887
Zolpidem (Ambien, Ivadal, Stilnox) 2783

Schedule V

Codeine Cough Preparation (Cosanyl, Pediacof) 9050
Difenoxin Preparation (Motofen) 9167
Dihydrocodeine Preparation (Cophene-S) 9120
Diphenoxylate Preparation (Lomotil, Logen) 9170
Ethylmorphine Preparation 9190
Opium Preparation (Kapectolin PG) 9809


Federal registration by DEA is based upon the applicant 's compliance with applicable state and local laws. Applicant should contact the local state licensing authority prior to completing this application. If your state requires a separate controlled substance number, provide that number on this application.


Applicant must answer all four questions for the application to be accepted for processing. If you answer "Yes" to a question, provide an explanation in the space provided. If you answer "Yes" to several questions, then you must provide a separate explanation describing the date, location, nature, and result of incident. If additional space is required, you may attach a separate page.


Exemption from payment of application fee is limited to federal, state or local government official or institution. The applicant's superior or agency officer must certify exempt status. The signature, authority title, and telephone number of the certifying official (other than the applicant) must be provided. The address of the fee exempt institution must appear in Section 1.


Indicate the desired method of payment. Make checks payable to "Drug Enforcement Administration". Third-party checks or checks drawn on foreign banks will not be accepted. FEES ARE NON-REFUNDABLE.


Applicant MUST sign in this section or application will be returned. Card holder signature in section 7 does not fulfill this requirement.

Notice to Registrants Making Payment by Check

Authorization to Convert Your Check: If you send us a check to make your payment, your check will be converted into an electronic fund transfer. "Electronic fund transfer" is the term used to refer to the process in which we electronically instruct your financial institution to transfer funds from your account to our account, rather than processing your check. By sending your completed, signed check to us, you authorize us to copy your check and to use the account information from your check to make an electronic fund transfer from your account for the same amount as the check. If the electronic fund transfer cannot be processed for technical reasons, you authorize us to process the copy of your check.

Insufficient Funds:

The electronic funds transfer from your account will usually occur with 24 hours, which is faster than a check is normally processed. Therefore, make sure there are sufficient funds available in your checking account when you send us your check. If the electronic funds transfer cannot be completed because of insufficient funds, we may try to make the transfer up to two more times.

Transaction Information:

The electronic fund transfer from your account will be on the account statement you receive from your financial institution. However, the transfer may be in a different place on your statement than the place where your checks normally appear. For example, it may appear under "other withdrawals" or "other transactions." You will not receive your original check back from your financial institution. For security reasons, we will destroy your original check, but we will keep a copy of the check for record-keeping purposes.

Your Rights:

You should contact your financial institution immediately if you believe that the electronic fund transfer reported on your account statement was not properly authorized or is otherwise incorrect. Consumers have protections under Federal law called the Electronic Fund Transfer Act for an unauthorized or incorrect electronic fund transfer.


No registration will be issued unless a completed application has been received (21 CFR 1301.13).

In accordance with the Paperwork Reduction Act of 1995, no person is required to respond to a collection of information unless it displays a valid OMB control number. The OMB number for this collection is 1117-0014. Public reporting burden for this collection of information is estimated to average 12 minutes per response, including the time for reviewing instructions, searching existing data sources, gathering and maintaining the data needed, and completing and reviewing the information.

The Debt Collection Improvements Act of 1996 (31 U.S.C. §7701) requires that you furnish your Taxpayer Identification Number (TIN) or Social Security Number (SSN) on this application. This number is required for debt collection procedures if your fee is not collectible.

PRIVACY ACT NOTICE: Providing information other than your SSN or TIN is voluntary; however, failure to furnish it will preclude processing of the application. The authorities for collection of this information are §§302 and 303 of the Controlled Substances Act (CSA) (21 U.S.C. §§822 and 823). The principle purpose for which the information will be used is to register applicants pursuant to the CSA. The information may be disclosed to other Federal law enforcement and regulatory agencies for law enforcement and regulatory purposes, State and local law enforcement and regulatory agencies for law enforcement and regulatory purposes, and persons registered under the CSA for the purpose of verifying registration. For further guidance regarding how your information may be used or disclosed, and a complete list of the routine uses of this collection, please see the DEA System of Records Notice "Controlled Substances Act Registration Records" (DEA-005), 52 FR 47208, December 11, 1987, as modified.


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TELEPHONE: HQ Call Center (800) 882-9539

WRITTEN INQUIRIES: DEA, Attn: Registration Section/DRR, P.O. Box 2639, Springfield, VA 22152-2639.

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