Office of Diversion Control, US Department of Justice, Drug Enforcement Administration

REGISTRATION > Applications, Tools & Resources > DEA Form 225 - New Application for Registration

DEA Form 225 - New Application for Registration

INSTRUCTIONS

This form is for new applicants. Any person who does not currently possess a DEA registration to conduct business with controlled substances in the following categories may access the application form. The categories of applicant who can apply using this form are manufacturers, distributors, importers, exporters, researchers and analytical laboratories.

Complete DEA Form 225 Online (If possible, you are encouraged to use the online forms system to apply for your registration.)

Note: Researchers with Schedule I drugs only must submit DEA 225 PDF application and the protocol found in 21 CFR 1301.18. You cannot apply online for your initial application.

Download DEA Form 225 (PDF) to apply via U.S. Postal Service.

Before you enter the form, you may wish to print the instruction pages (recommended) which will assist in completing the form. After completing the form, print, sign and mail to DEA.

INSTRUCTIONS

SECTION 1. APPLICANT IDENTIFICATION

SECTION 2. BUSINESS ACTIVITY

SECTION 3A. DRUG SCHEDULES

3B. MANUFACTURERS ONLY

3C. SCHEDULE CODES

TABLE OF SCHEDULES & DRUG CODES

SECTION 4. STATE LICENSE(S)

SECTION 5. LIABILITY

SECTION 6. EXEMPTION

SECTION 7. METHOD OF PAYMENT

SECTION 8. APPLICANT'S SIGNATURE

ATTACHMENTS:

NOTICE TO REGISTRANTS PAYING BY CHECK

ADDITIONAL INFORMATION

SECTION 1. APPLICANT IDENTIFICATION

Information must be typed or printed in the blocks provided to help reduce data entry errors. A physical address is required in address line 1; a post office box or continuation of address may be entered in address line 2. Fee exempt applicant must list the address of the fee exempt institution. Applicant must enter a valid social security number (SSN), or a tax identification number (TIN) if applying as a business entity.

Debt collection information is mandatory pursuant to the Debt Collection Improvement Act of 1996.

SECTION 2. BUSINESS ACTIVITY

Indicate only one. Each type of business activity requires a separate application. You are required to register as a "manufacturer" if you manufacture a controlled substance or list 1 chemical and then distribute it.

SECTION 3A. SCHEDULES

Applicant should check all schedules to be handled. However, applicant must still comply with state requirements; federal registration does not overrule state restrictions. Check the order form box only if you intend to purchase or to transfer schedule 1 and 2 controlled substances. Order forms will be mailed to the registered address following issuance of a Certificate of Registration.

3B. MANUFACTURER ONLY

Mark the chemical/controlled substance schedule(s) handled in each manufacturing stage listed.

3C. SCHEDULE CODES

Report all chemical/drug codes as required for your business activity. Controlled sustances manufacturers and importers must obtain a separate chemical registration if they handle chemicals other than an FDA-approved drug product containing 1225, 8112, or 8113.

SECTION 4. STATE LICENSE(S)

Federal registration by DEA is based upon the applicant's compliance with applicable state and local laws. Applicant should contact the local state licensing authority prior to completing this application. If your state requires a license, provide that number on this application.

SECTION 5. LIABILITY

Applicant must answer all four questions for the application to be accepted for processing. If you answer "Yes" to a question, provide an explanation in the space provided. If you answer "Yes" to several questions, then you must provide a separate explanation describing the date, location, nature, and result of each incident. If additional space is required, you may attach a separate page.

SECTION 6. EXEMPTION

Exemption from payment of application fee is limited to federal, state or local government official or institution. The applicant's superior or agency officer must certify exempt status. The signature, authority title, and telephone number of the certifying official (other than the applicant) must be provided. The address of the fee exempt institution must appear in Section 1.

SECTION 7. METHOD OF PAYMENT

Indicate the desired method of payment. Make checks payable to "Drug Enforcement Administration". Third-party checks or checks drawn on foreign banks will not be accepted. FEES ARE NON-REFUNDABLE.

SECTION 8. APPLICANT'S SIGNATURE

Applicant MUST sign in this section or application will be returned. Card holder signature in section 7 does not fulfill this requirement.

ATTACHMENTS:

Researcher or canine handler must attach 3 copies of protocol, including curriculum vitae, to conduct research with schedule 1 controlled substances. For clinical investigations, researcher must first submit to FDA a "Notice of Claimed Investigational Exemption for New Drug (IND)". See DEA web site or CFR 1301.18 for details.

NOTICE TO REGISTRANTS MAKING PAYMENT BY CHECK

Authorization to Convert Your Check:

If you send us a check to make your payment, your check will be converted into an electronic fund transfer. "Electronic fund transfer" is the term used to refer to the process in which we electronically instruct your financial institution to transfer funds from your account to our account, rather than processing your check. By sending your completed, signed check to us, you authorize us to copy your check and to use the account information from your check to make an electronic fund transfer from your account for the same amount as the check. If the electronic fund transfer cannot be processed for technical reasons, you authorize us to process the copy of your check.

Insufficient Funds:

The electronic funds transfer from your account will usually occur within 24 hours, which is faster than a check is normally processed. Therefore, make sure there are sufficient funds available in your checking account when you send us your check. If the electronic funds transfer cannot be completed because of insufficient funds, we may try to make the transfer up to two more times.

Transaction Information:

The electronic fund transfer from your account will be on the account statement you receive from your financial institution. However, the transfer may be in a different place on your statement than the place where your checks normally appear. For example, it may appear under "other withdrawals" or "other transactions". You will not receive your original check back from your financial institution. For security reasons, we will destroy your original check, but we will keep a copy of the check for record-keeping purposes.

Your Rights:

You should contact your financial institution immediately if you believe that the electronic fund transfer reported on your account statement was not properly authorized or is otherwise incorrect. Consumers have protections under Federal law called the Electronic Fund Transfer Act for an unauthorized or incorrect electronic fund transfer.

ADDITIONAL INFORMATION

No registration will be issued unless a completed application form has been received (21 CFR 1301.13).

In accordance with the Paperwork Reduction Act of 1995, no person is required to respond to a collection of information unless it displays a valid OMB control number. The OMB number for this collection is 1117-0012. Public reporting burden for this collection of information is estimated to average 12 minutes per response, including the time for reviewing instructions, searching existing data sources, gathering and maintaining the data needed, and completing and reviewing the information.

The Debt Collection Improvements Act of 1996 (31 U.S.C. §7701) requires that you furnish your Taxpayer Identification Number (TIN) or Social Security Number (SSN) on this application. This number is required for debt collection procedures if your fee is not collectible.

PRIVACY ACT NOTICE: Providing information other than your SSN or TIN is voluntary; however, failure to furnish it will preclude processing of the application. The authorities for collection of this information are §§302 and 303 of the Controlled Substances Act (CSA) (21 U.S.C. §§822 and 823). The principle purpose for which the information will be used is to register applicants pursuant to the CSA. The information may be disclosed to other Federal law enforcement and regulatory agencies for law enforcement and regulatory purposes, State and local law enforcement and regulatory agencies for law enforcement and regulatory purposes, and person registered under the CSA for the purpose of verifying registration. For further guidance regarding how your information may be used or disclosed, and a complete list of the routine uses of this collection, please see the DEA System of Records Notice "Controlled Substances Act Registration Records" (DEA-005), 52 FR 47208, December 11, 1987, as modified.

SCHEDULE AND DRUG CODES

Listed below are examples of schedules 1-5 and List 1 codes. Check all drug and chemical codes you handle as required.

If you bulk manufacture a substance, check the bulk column after the applicable drug code.

For more information, see our website at www.deadiversion.usdoj.gov, 21 CFR 1308, or call 1-800-882-9539.

Canine Handler must mark schedule 1
Exporter must mark all schedule 1-5
Importer must mark all schedule 1-5 & List 1 codes
Manufacturer must mark all schedule 1, 2 & List 1 codes
Distributor must mark all schedule 1, drug code 2012
Reverse Distributor must mark all schedule 1, drug code 2012
Researcher w/Sched 1 must mark schedule 1
Researcher w/Sched 2-5 must mark schedule 2 to be manufactured or imported
as part of research

 

SCHEDULE 1 NARCOTIC & NON-NARCOTIC CODE BULK?
  3,4-Methylenedioxyamphetamine (MDA) 7400  
  3,4-Methylenedioxymethamphetamine (MDMA) 7405  
  4-Methyl - 2,5 - Dimethoxyamphetamine (DOM, STP) 7395  
  4-Methylaminorex (cis isomer) (U4Euh, McN-422) 1590  
  Alphacetylmethadol (except LAAM) 9603  
  Bufotenine (Mappine) 7433  
  Marihuana / Cannabidiol 7360/7372  
  Diethyltryptamine (DET) ( 7434  
  Difenoxin 1MG/25UG AtSO4 /DU (Motofen) 9167  
  Dimethyltryptamine (DMT) 7435  
  Etorphine (except HCL) 9056  
  Gamma Hydroxybutyric Acid (GHB) 2010  
  Heroin (Diamorphine) 9200  
  Ibogaine 7260  
  Lysergic acid diethylamide (LSD) 7315  
  Mescaline 7381  
  Marihuana 7360  
  Methaqualone (Quaalude) 2565  
  Normorphine 9313  
  Peyote 7415  
  Psilocybin 7437  
  Tetrahydrocannabinols (THC) 7370  
SCHEDULE 2 NARCOTIC & NON-NARCOTIC CODE BULK?
  Amobarbital (Amytal, Tuinal) 2125  
  Amphetamine (Dexedrine, Adderall) 1100  
  Cocaine (Methyl benzoylecgonine) 9041  
  Codeine (Morphine methyl ester) 9050  
  Dextropropoxyphene (bulk) 9273  
  Diphenoxylate 9170  
  Fentanyl (Duragesic) 9801  
  Hydrocodone (Dihydrocodeinone) 9193  
  Hydromorphone (Diaudid) 9150  
  Levo-Alphacetylmethadol (LAAM) 9648  
  Levorphanol (Levo-Dromoran) 9220  
  Meperidine (Demerol, Mepergan) 9230  
  Methadone (Dolophine, Methadose) 9250  
  Methamphetamine (Desoxyn) 1105  
  Methylphenidate (Concerta, Ritalin) 1724  
  Morphine (MS Contin, Roxanol) 9300  
  Opium, powdered 9639  
  Oxycodone (Oxycontin, Percocet) 9143  
  Oxymorphone (Numorphan) 9652  
  Pentobarbital (bulk) (Nembutal) 2270  
  Phencyclidine (PCP) 7471  
  Secobarbital (Seconal, Tuinal) 2315  
SCHEDULE 3 NARCOTIC & NON-NARCOTIC CODE BULK?
  Anabolic Steroids 4000  
  Barbituric acid derivative 2100  
  Benzphetamine (Didrex, Inapetyl) 1228  
  Buprenorphine (Buprenex, Temgesic) 9064  
  Butabarbital 2100/2175  
  Butalbital 2100/2165  
  Codeine combo product (Empirin) 9804  
  Dihydrocodeine combo product (Compal) 9807  
  Dronabinol in sesame oil soft cap (Marinol) 7369  
  Gamma-Hydroxybutyric Acid preparations (Zyrem) 2012  
  Hydrocodone combo products (Lorcet, Vicodin) 9806  
  Ketamine (Ketaset, Ketalar) 7285  
  Morphine combo product 9810  
  Nalorphine (Nalline) 9400  
  Opium combo product (Paregoric) 9809  
  Pentobarbital suppository dosage (FP3) 2270  
  Phendimetrazine (Plegine, Bontril) 1615  
  Thiopental 2100/2329  
SCHEDULE 4 NARCOTIC & NON-NARCOTIC CODE BULK?
  Alprazolam (Xanax 2882  
  Barbital (Veronal, Plexonal) 2145  
  Chloral Hydrate (Noctec) 2465  
  Chlordiazepoxide (Librium) 2744  
  Clonazepam (Klonopin) 2737  
  Clorazepate (Tranxene) 2768  
  Diazepam (Valium) 2765  
  Flurazepam (Dalmane) 2767  
  Lorazepam (Ativan) 2885  
  Meprobamate (Milltown, Equanil) 2820  
  Midazolam (Versed) 2884  
  Oxazepam (Serax, Serenid-D) 2835  
  Phenobarbital (Fastin, Zantryl) 2285  
  Phentermine 1640  
  Temazepam (Restoril) 2925  
  Zolpidem (Ambien, Stilnox) 2783  
SCHEDULE 5 NARCOTIC & NON-NARCOTIC CODE BULK?
  Codeine preparations (Robitussin A-C, Pediacof) 9050  
  Pyrovalerone (Centroton, Thymergix) 1485  
LIST 1 REGULATED CHEMICALS
** ONLY manufacturers & importers may select List 1
CODE BULK?
  Ephedrine 8113  
  Phenylpropanolamine 1225  
  Pseudoephedrine 8112  

WRITE IN ADDITIONAL CODES

You may write in additional drug codes in this section. Attach a separate sheet if needed.

CONTACT INFORMATION

INTERNET: www.deadiversion.usdoj.gov

TELEPHONE: HQ Call Center (800) 882-9539

WRITTEN INQUIRIES: DEA, Attn: Registration Section/ODR, P.O. Box 2639, Springfield, VA 22152-2639.

All offices are listed on web site (800, 877, and 888 are toll-free)

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U.S. DEPARTMENT OF JUSTICE  •  DRUG ENFORCEMENT ADMINISTRATION
Office of Diversion Control  •  8701 Morrissette Drive  •  Springfield, VA 22152  •  1-800-882-9539